Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008458" target="_blank" >RIV/60461373:22330/03:00008458 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22640/03:00008458
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein
Original language description
The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV chan
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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