Intercalation of paracetamol into the hydrotalcite-like host

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F11%3A10109182" target="_blank" >RIV/00216208:11320/11:10109182 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/11:43891830
Result on the web
<a href="http://dx.doi.org/10.1016/j.jssc.2011.10.029" target="_blank" >http://dx.doi.org/10.1016/j.jssc.2011.10.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jssc.2011.10.029" target="_blank" >10.1016/j.jssc.2011.10.029</a>

Result language
angličtina
Original language name
Intercalation of paracetamol into the hydrotalcite-like host
Original language description
Hydrotalcite-like compounds are often used as host structures for intercalation of various anionic species. The product intercalated with the nonionic, water-soluble pharmaceuticals paracetamol, N-(4-hydroxyphenyl)acetamide, was prepared by rehydration of the Mg-Al mixed oxide obtained by calcination of hydrotalcite-like precursor at 500 degrees C. The successful intercalation of paracetamol molecules into the interlayer space was confirmed by powder X-ray diffraction and infrared spectroscopy measurements. Molecular simulations showed that the phenolic hydroxyl groups of paracetamol interact with hydroxide sheets of the host via the hydroxyl groups of the positively charged sites of Al-containing octahedra; the interlayer water molecules are located mostly near the hydroxide sheets. The arrangement of paracetamol molecules in the interlayer is rather disordered and interactions between neighboring molecules cause their tilting towards the hydroxide sheets. Dissolution tests in various
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP207%2F10%2F1447" target="_blank" >GAP207/10/1447: Photoactive hybrid materials</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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