Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F13%3A10143976" target="_blank" >RIV/00216208:11320/13:10143976 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/13:00392660 RIV/00216224:14740/13:00067549

Result on the web

<a href="http://dx.doi.org/10.1093/nar/gks1135" target="_blank" >http://dx.doi.org/10.1093/nar/gks1135</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gks1135" target="_blank" >10.1093/nar/gks1135</a>

Result language

angličtina

Original language name

Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study

Original language description

DNA concentration has been recently suggested to be the reason why different arrangements are revealed for K+-stabilized human telomere quadruplexes by experimental methods requiring DNA concentrations differing by orders of magnitude. As Raman spectroscopy can be applied to DNA samples ranging from those accessible by absorption and CD spectroscopies up to extremely concentrated solutions, gels and even crystals; it has been used here to clarify polymorphism of a core human telomeric sequence G(3)(TTAG(3))(3) in the presence of K+ and Na+ ions throughout wide range of DNA concentrations. We demonstrate that the K+-structure of G(3)(TTAG(3))(3) at low DNA concentration is close to the antiparallel fold of Na+-stabilized quadruplex. On the increase of G(3)(TTAG(3))(3) concentration, a gradual transition from antiparallel to intramolecular parallel arrangement was observed, but only for thermodynamically equilibrated K+-stabilized samples. The transition is synergically supported by incr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

1005-1016

UT code for WoS article

000314121100034

EID of the result in the Scopus database

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