Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F14%3A10283120" target="_blank" >RIV/00216208:11320/14:10283120 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00430431
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2013.11.038" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2013.11.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2013.11.038" target="_blank" >10.1016/j.febslet.2013.11.038</a>
Alternative languages
Result language
angličtina
Original language name
Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
Original language description
We report sphingolipid-related reorganization of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae using trans-Parinaric acid (t-PnA) and 1,6-diphenyl-1,3,5-hexatriene (DPH). Compared to control, the gel-like domains were significantly reduced in the membrane of a sphingolipid-deficient lcb1-100 mutant. The same reduction resulted from sphingolipid depletion by myriocin. The phenotype could be reverted when a myriocin-induced block in sphingolipid biosynthesis was bypassedby exogenous dihydrosphingosine. Lipid order of less-ordered membrane regions decreased with sphingolipid depletion as well, as documented by DPH fluorescence anisotropy. The data indicate that organization of lateral microdomains is an essential physiological role of these structural lipids. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP205%2F12%2F0720" target="_blank" >GAP205/12/0720: Role of membrane potential in the lateral microdomain organization of the plasma membrane</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
—
Volume of the periodical
588
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
443-449
UT code for WoS article
000329976800010
EID of the result in the Scopus database
—