The effects of sigma receptor ligand in isolated rat hearts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003344" target="_blank" >RIV/00216224:14110/00:00003344 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The effects of sigma receptor ligand in isolated rat hearts
Original language description
Sigma receptors originally discovered in central nervous system are present in many peripheral tissues, including heart muscle. Our previous experiments with sigma receptor ligands in rat myocytes suggested that these receptors may play a role in modulation of contractility. Sigma receptor binding has been reported to severely impair the regular rhythm in cell cultures probably due to increased [Ca2+]i. The aim of the present study was to prove these effects of highly selective sigma ligand BD737 in thewhole heart. In analogy to the positive inotropic effect in isolated stimulated myocytes, BD737 exerted a slight but significant increase of systolic pressure in perfused hearts. The most typical feature of the effect in both models is a loss of stability. In spontaneously active hearts, the heart rate fluctuates at the rate of 2-3 cycles per minute. This rate is characteristic for IP3 production and [Ca2+]i oscillations. In the present experiments ventricular ectopic beats and periods
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GA305%2F98%2FP206" target="_blank" >GA305/98/P206: The effect of sigma receptors on contractility and membrane currents in mammalian myocardium</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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