Effects of sigma ligand haloperidol on isolated heart.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003426" target="_blank" >RIV/00216224:14110/00:00003426 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effects of sigma ligand haloperidol on isolated heart.
Original language description
It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Sigma receptors were originally discovered in central nervous system, but they are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes suggested that these receptors may play a role in modulation of contractility. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias such as torsade de pointes, ventricular fibrillation and other life-threatening complications are well known and have been repeatedly reported. The aim of the present study was to investigate the effects of sigma receptor ligand haloperidol in the whole heart preparation.Previously described arrhythmogenic effec
Czech name
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Czech description
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Project
<a href="/en/project/GA305%2F98%2FP206" target="_blank" >GA305/98/P206: The effect of sigma receptors on contractility and membrane currents in mammalian myocardium</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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