Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F01%3APU20112" target="_blank" >RIV/00216305:26220/01:PU20112 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart
Original language description
Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Halooperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-ti
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA102%2F01%2F1494" target="_blank" >GA102/01/1494: Optical recording of action potentials and its application in cardiology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Medicon 2001, iX Mediterranean Conference on Medical and BIological Engineering and Computing
ISBN
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ISSN
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e-ISSN
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Number of pages
4
Pages from-to
418-421
Publisher name
International Federation for MEdical and Biological Engineering
Place of publication
Pula, Chorvatsko
Event location
Pula, Croatia
Event date
Jun 12, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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