Wavelet analysis of the effect of sigma ligand haloperidol on isolated rat heart.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004291" target="_blank" >RIV/00216224:14110/01:00004291 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Wavelet analysis of the effect of sigma ligand haloperidol on isolated rat heart.
Original language description
Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that they might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics in the heart. Haloperidol is a typical sigma ligand used in everyday clinical practice with well known and repeatedly reported side effects. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in signal morphology.
Czech name
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Czech description
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Project
<a href="/en/project/GA305%2F98%2FP206" target="_blank" >GA305/98/P206: The effect of sigma receptors on contractility and membrane currents in mammalian myocardium</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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