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Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004148" target="_blank" >RIV/00216224:14110/01:00004148 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

  • Original language description

    Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2001

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Genetics and Metabolism

  • ISSN

    1096-7192

  • e-ISSN

  • Volume of the periodical

    2

  • Issue of the periodical within the volume

    73

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    188

  • UT code for WoS article

  • EID of the result in the Scopus database