The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F12%3A00387180" target="_blank" >RIV/67985904:_____/12:00387180 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/12:00064959

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction

Original language description

OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within methionine-homocysteine pathway and, consequently, in the development of vascular diseases. The C677T polymorphism (rs1801133) of the MTHFR gene affects the MTHFR activity, modifies the homocysteine plasma concentration and, among others, increases the risks for idiopathic male infertility, including erectile dysfunction (ED). As this sexual dysfunction is related to sexhormone levels, we investigated a possible relationship between the C677T polymorphism of the MTHFR gene and plasma concentrations of follicle-stimulating hormone (FSH) as well as luteinizing hormone (LH) in male patients with ED. METHODS: We conductedour study on 90 healthy men with ED between the age of 32 and 61 (mean age was 51.1 +/- 11.5) years. The subjects were genotyped and their FSH and LH plasma levels were analysed. RESULTS: The analysis results of ED patients and their geno

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT11152" target="_blank" >NT11152: Epidemiology and genetics of Alzheimer´s disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

5

Country of publishing house

SE - SWEDEN

Number of pages

6

Pages from-to

101-106

UT code for WoS article

000311470400006

EID of the result in the Scopus database

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