Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00071796" target="_blank" >RIV/00216224:14310/13:00071796 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/13:00428603 RIV/61988987:17110/13:A1501A3S
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia
Original language description
Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. Methods: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR677 CT + TT genotype was found (OR=1.6, P=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met and ADRA2A C-1291G polymorphisms previously associated with schizophrenia risk using a logistic regression analysis. Results: Previous studies of MTHFR*COMT (C677T*Val158Met) interaction in relation to schizophrenia resulted in inconsistent results.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NT14504" target="_blank" >NT14504: Epidemiology and genetics of schizophrenia</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology Letters
ISSN
0172-780X
e-ISSN
—
Volume of the periodical
34
Issue of the periodical within the volume
8
Country of publishing house
LU - LUXEMBOURG
Number of pages
6
Pages from-to
792-797
UT code for WoS article
000331786100010
EID of the result in the Scopus database
—