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The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00009923" target="_blank" >RIV/00216224:14110/04:00009923 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour

  • Original language description

    The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.

  • Czech name

    Vliv agonsity kanabinoidních CB2 receptotů na rozvoj sensitizace k metafetaminovým účinkům na agonistické chování myší

  • Czech description

    Premedikace opakovým podáním agonisty kanabinoidních CB2 receptorů, JWH 015, nevyvolala zkříženou sensitizaci k antiagresivním účinkům metamfetaminu u myší.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Psychiatrie

  • ISSN

    1211-7579

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    Suppl. 1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    1

  • Pages from-to

    54-54

  • UT code for WoS article

  • EID of the result in the Scopus database