The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010239" target="_blank" >RIV/00216224:14110/04:00010239 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
Original language description
The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.
Czech name
Vliv agonisty kanabinoidního receptoru CB2 JWH015 na rozvoj sensitizace v modelu agonistického chování myší
Czech description
Rozvoj behaviorální sensitizace k antiagresivnímu účinku metamfetaminu u myší není vyvolán premedikací agonistou CNB2 kanabinoidních receptorů JWH015.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Homeostasis in Health and Diseases
ISSN
0960-7560
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
2
Pages from-to
41-42
UT code for WoS article
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EID of the result in the Scopus database
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