Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010573" target="_blank" >RIV/00216224:14110/04:00010573 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment

Original language description

Experimental model based on the C5 ventral root avulsion was used to evaluate the efficacy of brainderived neurotrophic factor (BDNF) and Cerebrolysin treatment on motor neuron maintenance and survival resulted in the functional reinnervation of the nerve stump. In contrast to vehicle, BDNF treatment reduced the loss and atrophy of motor neurons and enhanced the regrowth axon sprouts into the distal stump of musculocutaneous nerve. However, the axon diameter of the myelinated fibers was smaller than those of control rats. The morphometric results were related to a low score in behavioral test similar to vehicle-treated rats. Cerebrolysin treatment greatly protected the motor neurons against cell death. Moreover, morphometric features of myelinated axons were better than those of rats treated with vehicle or BDNF. The mean score of grooming test suggested better results of the functional motor reinnervation than after BDNF administration. The majority of rescued motor neurons regenerati

Czech name

Reinervace pahýlu nervus musculocutaneous po jeho přímém spojení s C5 míšním segmentem

Czech description

Byl použit vlastní experimentální model, ve které byla provedena avulze ventrálního kořene C5 spinálního nervu. Distální pyhýl n. musculocutaneus byl nasledně přímo spojen s C5 míšním segmentem. Byl testován vliv intrathekálního kontinuálního podávání BDNF a Cerebrolysinu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NF6658" target="_blank" >NF6658: Alternative approaches in brachial plexus reconstruction and experimental evaluation of various neurotrophic factors action on direct and collateral reinnervation</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Brain Research

ISSN

0014-4819

e-ISSN

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Volume of the periodical

159

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

425-432

UT code for WoS article

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EID of the result in the Scopus database

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