Nuclear organization of PML bodies in leukaemic and multiple myeloma cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00024442" target="_blank" >RIV/00216224:14110/08:00024442 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/08:00313832 RIV/65269705:_____/08:#0000195
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nuclear organization of PML bodies in leukaemic and multiple myeloma cells
Original language description
The nuclear arrangement of promyelocytic leukaemia nuclear bodies (PML NBs) was studied in vitro after the cell treatment by clinically used agents such as all-trans retinoic acid (RA) in human leukaemia and cytostatics or gamma radiation in multiple myeloma cells. Here we showed correlations between the number of PML NBs and average Centre-to-PML distances. Moreover, a number of cells in S phase, especially during differentiation, influenced number of PML NBs. Studying the proteins involved in PML compartment, such as c-MYC, cell-type specific association of c-MYC and the PML NBs was observed in selected leukaemic cells undergoing differentiation, which was accompanied by c-MYC down-regulation.
Czech name
Organizace PML jaderných tělísek v leukemických a myelomových buňkách
Czech description
V této práci je studována organizace PML jaderných tělísek v leukemických a myelomových buňkách.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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