Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00028212" target="_blank" >RIV/00216224:14110/08:00028212 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Genetic variability in the pentose phosphate cycle enzymes as a treatment-independent modifier of hyperglycemia toxicity in diabetic nephropathy
Original language description
Introduction and Aims: Variable degree of more or less permanent hyperglycemia characterising diabetes mellitus (DM) is causally responsible for the development of diabetic complications including diabetic nephropathy (DN). Complex dysregulation of cellular metabolism during hyperglycemia - especially accumulation of proximal glycolytic intermediates - provides substrates for certain alternative metabolic pathways (polyol, hexosamine, non-enzymatic glycation etc.) giving rise to harmful moieties (advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc.). Pentose phosphate pathway (PPP) represents potentially protective mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions supposedly disburdens glycolysis and quantitatively limits processing of glycolytic intermediates in the alternative metabolic pathways.
Czech name
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Czech description
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Project
<a href="/en/project/NR9443" target="_blank" >NR9443: Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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