Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00028213" target="_blank" >RIV/00216224:14110/08:00028213 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Thiamine Status and Genetic Variability in the Pentose Phosphate Cycle Enzymes as Risk Factors for Diabetic Nephropathy
Original language description
Diabetic complications including diabetic nephropathy (DN) develop due to the complex dysregulation of cellular metabolism during hyperglycemia. Accumulation of proximal glycolytic intermediates provides substrates for several alternative metabolic pathways producing harmful moieties such as advanced glycation end-products, dicarbonyls, sorbitol, hexosamines, reactive oxygen and nitrogen species etc. Pentose phosphate pathway (PPP) represents potentially "protective" mechanism in hyperglycemia since shunting of cumulated glycolytic intermediates (esp. triosephosphates) into the PPP reactions quantitatively limits their processing in alternative metabolic pathways. We hypothesized that genetic variability in genes encoding key enzymes of PPP - transketolase (TKT), transaldolase, TKT-like and glucose-6-phosphate dehydrogenase - together with thiamin status (thiamine and its esters - cofactors of TKT) might contribute to an interindividual variability in the onset and progression of DN.
Czech name
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Czech description
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Project
<a href="/en/project/NR9443" target="_blank" >NR9443: Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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