Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00037270" target="_blank" >RIV/00216224:14110/09:00037270 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens

Original language description

Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number oftherapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA.No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patients skin symptoms resolved completely and thevalues of CRP and hemoglobin normalized.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LC06027" target="_blank" >LC06027: University Research Centre - Czech Myeloma Group</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Therapy

ISSN

1543-9135

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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