Schnitzlers syndrome - complete resolution of symptoms on treatment with anakinra after 12 yers of unsuccessful therapy with other regimens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F09%3A%230000738" target="_blank" >RIV/65269705:_____/09:#0000738 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Schnitzlers syndrome - complete resolution of symptoms on treatment with anakinra after 12 yers of unsuccessful therapy with other regimens

Original language description

Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number oftherapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA.No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patient?s skin symptoms resolved completely and the values of CRP and hemoglobin normalized.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Therapy

ISSN

1543-9135

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

Issue A

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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