Anti-Angiogenic Therapies for Children with Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00056963" target="_blank" >RIV/00216224:14110/10:00056963 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/156800910793357899" target="_blank" >http://dx.doi.org/10.2174/156800910793357899</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/156800910793357899" target="_blank" >10.2174/156800910793357899</a>
Alternative languages
Result language
angličtina
Original language name
Anti-Angiogenic Therapies for Children with Cancer
Original language description
Tumor angiogenesis, i.e. the development of neovascularisation in and around solid tumors, plays a key role in the local and distant growth of cancer and anti-angiogenic treatments are now established strategies to treat cancer patients. Specific inhibitors of angiogenesis such as bevacizumab or receptor tyrosine kinase inhibitors targeting VEGFR or PDGFR are now in clinical trials and are being increasingly validated for the treatment of poor prognostic cancers. Other anti-angiogenic strategies such ascilengitide or metronomic chemotherapy (low-dose anti-angiogenic chemotherapy) have been developed to treat certain types of adult cancer. In children, the clinical potential of anti-angiogenic approach is still in an early stage of investigation. Thisreview will focus on the role of angiogenesis in pediatric solid tumors and will describe the pre-clinical and clinical experience with several anti-angiogenic compounds as a potential treatment for children with cancer.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9341" target="_blank" >NR9341: Modulation of antineoplastic effect of retinoids by LOX/COX inhibitors on the model of solid childhood tumors: in vitro study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Cancer Drug Targets
ISSN
1568-0096
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
8
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
11
Pages from-to
879-889
UT code for WoS article
000285777300011
EID of the result in the Scopus database
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