Implications of flavonoids as potential modulators of cancer neovascularity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F20%3A43878610" target="_blank" >RIV/62157124:16370/20:43878610 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00116475 RIV/00159816:_____/20:00073200
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00432-020-03383-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs00432-020-03383-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00432-020-03383-8" target="_blank" >10.1007/s00432-020-03383-8</a>
Alternative languages
Result language
angličtina
Original language name
Implications of flavonoids as potential modulators of cancer neovascularity
Original language description
Purpose The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. Methods This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. Results and conclusion Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cancer Research and Clinical Oncology
ISSN
0171-5216
e-ISSN
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Volume of the periodical
146
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
3079-3096
UT code for WoS article
000567736000003
EID of the result in the Scopus database
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