Angiomodulators in cancer therapy: New perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876011" target="_blank" >RIV/62157124:16370/17:43876011 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biopha.2017.02.071" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.02.071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2017.02.071" target="_blank" >10.1016/j.biopha.2017.02.071</a>

Result language

angličtina

Original language name

Angiomodulators in cancer therapy: New perspectives

Original language description

The formation of new blood vessels plays a crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including carcinogenesis. Angiogenesis inhibitors (anti-angiogenics) are an important part of treatment for some types of cancer. Some natural products isolated from marine invertebrates have revealed antiangiogenic activities, which are diverse in structure and mechanisms of action. Many preclinical studies have generated new models for further modification and optimization of anti-angiogenic substances, and new information for mechanistic studies and new anti-cancer drug candidates for clinical practice. Moreover, in the last decade it has become apparent that galectins are important regulators of tumor angiogenesis, as well as microRNA. MicroRNAs have been validated to modulate endothelial cell migration or endothelial tube organization. In the present review we summarize the current knowledge regarding the role of marine-derived natural products, galectins and microRNAs in tumor angiogenesis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicine &amp; pharmacotherapy

ISSN

0753-3322

e-ISSN

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Volume of the periodical

89

Issue of the periodical within the volume

May

Country of publishing house

FR - FRANCE

Number of pages

13

Pages from-to

578-590

UT code for WoS article

000402468200068

EID of the result in the Scopus database

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