Statins in oncological research: From experimental studies to clinical practice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00074348" target="_blank" >RIV/00216224:14110/14:00074348 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061204
Result on the web
<a href="http://dx.doi.org/10.1016/j.critrevonc.2014.08.002" target="_blank" >http://dx.doi.org/10.1016/j.critrevonc.2014.08.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.critrevonc.2014.08.002" target="_blank" >10.1016/j.critrevonc.2014.08.002</a>
Alternative languages
Result language
angličtina
Original language name
Statins in oncological research: From experimental studies to clinical practice
Original language description
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many epidemiological and preclinical studies pointed to anti-tumor properties of statins, including anti-proliferative activities, apoptosis, decreased angiogenesis and metastasis. These processes play an important role in carcinogenesis and, therefore, the role of statins in cancer disease is being seriously discussed among oncologists. Anti-neoplastic properties of statins combined with an acceptable toxicity profile in the majority of individuals support their further development as anti-tumor drugs.The mechanism of action, current preclinical studies and clinical efficacy of statins are reviewed in this paper. Moreover, promising results have been reported regarding the statins' efficacy in some cancer types, especially in esophageal and colorectal cancers, and hepatocellular carcinoma.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Critical Reviews in Oncology/Hematology
ISSN
1040-8428
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
296-311
UT code for WoS article
000347130000012
EID of the result in the Scopus database
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