Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00061172" target="_blank" >RIV/00216224:14110/12:00061172 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/12:00390339 RIV/00159816:_____/12:#0000942

Result on the web

<a href="http://dx.doi.org/10.1038/pcan.2012.6" target="_blank" >http://dx.doi.org/10.1038/pcan.2012.6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/pcan.2012.6" target="_blank" >10.1038/pcan.2012.6</a>

Result language

angličtina

Original language name

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Original language description

Deregulation of expression and function of cytokines belonging to the transforming growth factor-ß (TGF-ß) family is often associated with various pathologies. For example, this cytokine family has been considered a promising target for cancer therapy. However, the detailed functions of several cytokines from the TGF-ß family that could play a role in cancer progression and therapy remain unclear. One of these molecules is growth/differentiation factor-15 (GDF-15), a divergent member of the TGF-ß family. This stress-induced cytokine has been proposed to possess immunomodulatory functions, and its high expression is often associated with cancer progression, including prostate cancer. However, studies clearly demonstrating the mechanisms for signal transduction and functions in cell interaction, cancer progression, and therapy are still lacking. New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for prostate cancer bone metastases.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prostate Cancer And Prostatic Diseases

ISSN

1365-7852

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

320-328

UT code for WoS article

000311034200003

EID of the result in the Scopus database

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