The effects of TGFb proteins on osteoclast differentiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00024950" target="_blank" >RIV/00216224:14310/08:00024950 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effects of TGFb proteins on osteoclast differentiation

Original language description

Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect thebone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of os

Czech name

Vliv proteinů rodiny TGFb na diferenciaci osteoklastů

Czech description

Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect thebone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as.In contrast, the BMP-7 and GDF-15 cytokines suppressedthe RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of ost

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine

ISBN

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ISSN

1107-3756

e-ISSN

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Number of pages

1

Pages from-to

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Publisher name

International Journal of Molecular Medicine Vol. 22, supplement 1, 2008

Place of publication

Hersonissos, Greece

Event location

Hersonissos, Greece

Event date

Nov 9, 2008

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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