Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00036202" target="_blank" >RIV/00216224:14310/09:00036202 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts
Original language description
Prostate cancer is a common disease in industrial countries. Prostate tumors preferentially disseminate to bones and induce significant rearrangement of the bone architecture. T The aim of this study is to characterize effects of growth differentiation factor-15 (GDF-15) secreted by prostate cancer cells on the osteoclastic differentiation pathway. This study documents that GDF-15 both as purified substance and as unpurified product secreted by prostate cancer cells strongly interferes with differentiation of osteoclasts by inhibiting expression and activity of NFkB and c-Fos. This work was supported by grants 301/09/1115 (JS), 204/07/0834 (KS), 310/07/0961 (KS) of the Czech Science Foundation, MSM0021622415 of Ministry of Education, Youth and Sports of the Czech Republic (JS) and AV0Z50040507 of the Grant Agency of Academy of Sciences of the Czech Republic (KS).
Czech name
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Czech description
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Project
<a href="/en/project/GA301%2F09%2F1115" target="_blank" >GA301/09/1115: The role of c-Myb and Cox-2 proteins in colon carcinogenesis</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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