Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00061849" target="_blank" >RIV/00216224:14110/12:00061849 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/j.1582-4934.2012.01614.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2012.01614.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1582-4934.2012.01614.x" target="_blank" >10.1111/j.1582-4934.2012.01614.x</a>

Result language

angličtina

Original language name

Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy

Original language description

Dendritic cell (DC) immunotherapy is capable of generating tumour-specific immune responses. Different maturation strategies were previously tested to obtain DC capable of anti-cancer responses in vitro, usually with limited clinical benefit. Mutual comparison of currently used maturation strategies and subsequent complex evaluation of DC functions and their stimulatory capacity on T cells was performed in this study to optimize the DC vaccination strategy for further clinical application. DC were generated from monocytes using granulocyte?macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, pulsed with whole tumour cell lysate and then matured with one of five selected maturation strategies or cultured without additional maturation stimulus. DC were characterized with regard to their surface marker expression, cytokine profiles, migratory capacity, allogeneic and autologous T cell stimulatory capacity as well as their specific cytotoxicity against tumour antigens.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Cellular and Molecular Medicine

ISSN

1582-1838

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

2827-2837

UT code for WoS article

000310555200026

EID of the result in the Scopus database

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