Determination of 8-hydroxy-2´-deoxyguanosine in urine by high-performance liquid chromatography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062934" target="_blank" >RIV/00216224:14110/12:00062934 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Determination of 8-hydroxy-2´-deoxyguanosine in urine by high-performance liquid chromatography
Original language description
Reactive oxygen species (ROS) are continuously formed in cell metabolism. Under pathological conditions, there is imbalance between prooxidative and antioxidative processes. ROS cause oxidative damage to cell macromolecules ? proteins as well as lipids,but damage on DNA possesses the biggest importance. In our study, the method for analysis of urinary 8OHdG by HPLC was developed. The method is based on SPE purification follows by HPLC with coulometric detection.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů