All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00066406" target="_blank" >RIV/00216224:14110/13:00066406 - isvavai.cz</a>

  • Alternative codes found

    RIV/00159816:_____/13:00060678

  • Result on the web

    <a href="http://dx.doi.org/10.1038/emboj.2013.9" target="_blank" >http://dx.doi.org/10.1038/emboj.2013.9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/emboj.2013.9" target="_blank" >10.1038/emboj.2013.9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

  • Original language description

    Completion of DNA replication needs to be ensured even when challenged with fork progression problems or DNA damage. PCNA and its modifications constitute a molecular switch to control distinct repair pathways. In yeast, SUMOylated PCNA (S-PCNA) recruitsSrs2 to sites of replication where Srs2 can disrupt Rad51 filaments and prevent homologous recombination (HR). We report here an unexpected additional mechanism by which S-PCNA and Srs2 block the synthesis-dependent extension of a recombination intermediate, thus limiting its potentially hazardous resolution in association with a cross-over. This new Srs2 activity requires the SUMO interaction motif at its C-terminus, but neither its translocase activity nor its interaction with Rad51. Srs2 binding toS-PCNA dissociates Pol delta and Pol eta from the repair synthesis machinery, thus revealing a novel regulatory mechanism controlling spontaneous genome rearrangements.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    EMBO JOURNAL

  • ISSN

    0261-4189

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    742-755

  • UT code for WoS article

    000316468000014

  • EID of the result in the Scopus database