A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00074018" target="_blank" >RIV/00216224:14110/14:00074018 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061210
Result on the web
<a href="http://dx.doi.org/10.1016/j.celrep.2014.08.054" target="_blank" >http://dx.doi.org/10.1016/j.celrep.2014.08.054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2014.08.054" target="_blank" >10.1016/j.celrep.2014.08.054</a>
Alternative languages
Result language
angličtina
Original language name
A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
Original language description
DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that the budding yeast Saw1 scaffold is more versatile. It helps cells cope with base lesions and protein-DNA adducts through its known function of recruiting the Rad1-Rad10 nuclease to DNA. In addition, it promotes UV survival via a mechanism mediated by its sumoylation. Saw1 sumoylation favors its interaction with another nuclease Slx1-Slx4, and this SUMO-mediated role is genetically separable from two main UV lesion repair processes. These effects of Saw1 and its sumoylation suggest that Saw1 is a multifunctionalscaffold that can facilitate diverse types of DNA repair through its modification and nuclease interactions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
143-152
UT code for WoS article
000344468100014
EID of the result in the Scopus database
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