Effect of spironolactone in patients with resistant arterial hypertension in relation to age and sex: Insights from the aspirant trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077045" target="_blank" >RIV/00216224:14110/14:00077045 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/14:33151449 RIV/00098892:_____/14:#0000781

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.105" target="_blank" >http://dx.doi.org/10.5507/bp.2012.105</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.105" target="_blank" >10.5507/bp.2012.105</a>

Result language

angličtina

Original language name

Effect of spironolactone in patients with resistant arterial hypertension in relation to age and sex: Insights from the aspirant trial

Original language description

Methods. Patients with an office systolic blood pressure (BP) &gt;140 mmHg or diastolic BP &gt;90 mmHg, despite treatment with at least 3 antihypertensive drugs including a diuretic, were randomly assigned to receive spironolactone or a placebo for 8 weeks in a double-blind, placebo-controlled, multicentre trial (ASPIRANT). Background. There are currently limited data on whether the effect of spironolactone in patients with resistant arterial hypertension depends on age and sex. Results. Analyses were done on 55 patients treated with spironolactone and 56 patients treated with placebo. Significant reductions of office systolic BP (-8.9 +/- 6.7 mmHg, P=0.012), 24-h ABPM systolic BP (-7.9 +/- 7.2 mmHg, P=0.032) and ABPM day-time systolic BP (-7.5 +/- 7.1mmHg) after 8 weeks of spironolactone treatment, compared to placebo, were only observed in patients with a median age 62 years, and is effective to a similar extent in men and women.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic

ISSN

1213-8118

e-ISSN

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Volume of the periodical

158

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

384-390

UT code for WoS article

000345398500009

EID of the result in the Scopus database

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