Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT) : study protocol
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F11%3A00102106" target="_blank" >RIV/00843989:_____/11:00102106 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/11:A12014HS
Result on the web
<a href="http://dx.doi.org/10.5507/bp.155.2011.004143" target="_blank" >http://dx.doi.org/10.5507/bp.155.2011.004143</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.155.2011.004143" target="_blank" >10.5507/bp.155.2011.004143</a>
Alternative languages
Result language
angličtina
Original language name
Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT) : study protocol
Original language description
Background. There is currently limited data on which drug should be used to improve blood pressure control in patients with resistant hypertension. Recent observational trials reported spironolactone as having good effects. This study is designed to assess the effect of the addition of 25 mg of spironolactone on blood pressure (BP) in patients with resistant arterial hypertension. Methods. Patients with office systolic BP > 140 mmHg or diastolic BP > 90 mmHg despite treatment with at least 3 antihypertensive drugs including a diuretic, are enrolled in this double-blind, placebo-controlled, multicentre trial. Patients are randomly assigned to receive spironolactone or a placebo at a ratio of 1:1 by the method of simple randomisation. Our primary endpoints are to show a statistically significant difference in the fall of mean day-time systolic and diastolic BP by ambulatory blood pressure monitoring (ABPM), between the spironolactone and placebo groups, after 8 weeks of treatment. Second
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
Vol.155
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
143-148
UT code for WoS article
000294040300006
EID of the result in the Scopus database
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