RECQ4 selectively recognizes Holliday junctions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00080936" target="_blank" >RIV/00216224:14110/15:00080936 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/15:00062876
Result on the web
<a href="http://dx.doi.org/10.1016/j.dnarep.2015.02.020" target="_blank" >http://dx.doi.org/10.1016/j.dnarep.2015.02.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dnarep.2015.02.020" target="_blank" >10.1016/j.dnarep.2015.02.020</a>
Alternative languages
Result language
angličtina
Original language name
RECQ4 selectively recognizes Holliday junctions
Original language description
The RECQ4 protein belongs to the RecQ helicase family, which plays crucial roles in genome maintenance. Mutations in the RECQ4 gene are associated with three insidious hereditary disorders: Rothmund Thomson, Baller-Gerold, and RAPADILINO syndromes. Thesesyndromes are characterized by growth deficiency, radial ray defects, red rashes, and higher predisposition to malignancy, especially osteosarcomas. Within the RecQ family, RECQ4 is the least characterized, and its role in DNA replication and repair remains unknown. We have identified several DNA binding sites within RECQ4. Two are located at the N-terminus and one is located within the conserved helicase domain. N-terminal domains probably cooperate with one another and promote the strong annealing activity of RECQ4. Surprisingly, the region spanning 322-400 aa shows a very high affinity for branched DNA substrates, especially Holliday junctions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DNA Repair
ISSN
1568-7864
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
"neuvedeno"
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
80-89
UT code for WoS article
000355050800009
EID of the result in the Scopus database
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