Calprotectin and lactoferrin in the cerebrospinal fluid; biomarkers utilisable for differential diagnostics of bacterial and aseptic meningitis?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082982" target="_blank" >RIV/00216224:14110/15:00082982 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/15:00063002

Result on the web

<a href="http://dx.doi.org/10.1515/cclm-2014-0775" target="_blank" >http://dx.doi.org/10.1515/cclm-2014-0775</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2014-0775" target="_blank" >10.1515/cclm-2014-0775</a>

Result language

angličtina

Original language name

Calprotectin and lactoferrin in the cerebrospinal fluid; biomarkers utilisable for differential diagnostics of bacterial and aseptic meningitis?

Original language description

Background: The aim of our work was to assess the diagnostic contribution of calprotectin and lactoferrin determinations in the cerebrospinal fluid when distinguishing between bacterial and aseptic meningitides. Methods: In 23 patients with bacterial meningitis (BM) and in 50 patients with aseptic meningitis (AM), we determined the concentrations of calprotectin, lactoferrin and the conventional biomarkers like glucose, total protein, lactate and polynuclear count in the cerebrospinal fluid (CSF). The discriminative power of the various parameters studied was determined by means of receiver operating characteristic (ROC) curves: the area under the curve (AUC), sensitivity, specificity, the positive likelihood ratio (+LR), and the negative likelihood ratio (-LR). Results: The diagnostic efficiency of calprotectin, lactoferrin, lactate, and polynuclear count when distinguishing between bacterial and aseptic meningitides, expressed by ROC curve parameters, was as follows: AUC (0.736, 0.94

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry and Laboratory medicine

ISSN

1434-6621

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

599-603

UT code for WoS article

000350674500021

EID of the result in the Scopus database

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