Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071978" target="_blank" >RIV/65269705:_____/19:00071978 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112735 RIV/75010330:_____/19:00012891

Result on the web

<a href="https://biomed.papers.upol.cz/pdfs/bio/2019/04/11.pdf" target="_blank" >https://biomed.papers.upol.cz/pdfs/bio/2019/04/11.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2018.082" target="_blank" >10.5507/bp.2018.082</a>

Result language

angličtina

Original language name

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis

Original language description

Aims. Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. Patients and Methods. This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent. Results. Boys with EV meningitis predominated over girls. The average patient age was 11 years. Compared to the control group, these patients suffered more from stiff back (P=0.010), vomiting and nausea (P=0.009). They had shorter symptom duration (P&lt;0.001), higher C-reactive protein in blood (P&lt;0.001), higher predominance of polynuclears (P=0.026), and greater lactate (P=0.003) in cerebrospinal fluid (CSF). The serotype seen most frequently (68%) was ECHO virus (ECV) 30. Conclusions. Enteroviruses play the most important role in the differential diagnosis of aseptic meningitis. Short symptom duration, slightly higher inflammatory parameters in blood, predominance of polynuclears, and elevated CSF lactate have predictive value in diagnosing this disease. ECV 30 (frequently the agent of epidemics in the Czech Republic) was the aseptic meningitis agent most often seen.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30100 - Basic medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

163

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

355-361

UT code for WoS article

000506054400011

EID of the result in the Scopus database

2-s2.0-85073942179