A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00087037" target="_blank" >RIV/00216224:14110/15:00087037 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/15:#0000602
Result on the web
<a href="http://dx.doi.org/10.1038/ncomms6751" target="_blank" >http://dx.doi.org/10.1038/ncomms6751</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms6751" target="_blank" >10.1038/ncomms6751</a>

Result language
angličtina
Original language name
A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Original language description
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)