Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00092433" target="_blank" >RIV/00216224:14110/15:00092433 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1177/1721727X15618671" target="_blank" >http://dx.doi.org/10.1177/1721727X15618671</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1721727X15618671" target="_blank" >10.1177/1721727X15618671</a>
Alternative languages
Result language
angličtina
Original language name
Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation
Original language description
The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-10 and TGF-beta after single and repeated administration of the drug. To study the effect of a single and repeated dose fluoxetine on carrageenan-induced paw edema male Wistar rats were divided into five groups (n = 8): control group; positive control group; and three experimental groups treated with 5, 10, and 20 mg/kg bodyweight (bw) fluoxetine, respectively. To study the effect of a single and repeated dose of fluoxetine on serum cytokine levels, the animals were divided in four groups (n = 8): two control groups treated with saline and two experimental groups treated with fluoxetine 20 mg/kg bw. Carrageenan and LPS were injected immediately after fluoxetine or saline injection.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Inflammation
ISSN
1721-727X
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
173-182
UT code for WoS article
000365744100005
EID of the result in the Scopus database
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