Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43872673" target="_blank" >RIV/62157124:16370/14:43872673 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.fct.2014.07.022" target="_blank" >http://dx.doi.org/10.1016/j.fct.2014.07.022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fct.2014.07.022" target="_blank" >10.1016/j.fct.2014.07.022</a>

Result language
angličtina
Original language name
Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats.
Original language description
The aim of the present study was to evaluate the possible protective effect of polydatin (PD) on cisplatin (Cis) induced oxidative stress in rats. Totally, thirty male Wistar albino rats were fed standard rodent diet and divided into 5 equal groups: thecontrol group (vehicle treated) was treated with physiological saline for ten days both orally and intraperitoneally (i.p.), the second group was orally treated with physiological saline and 7 mg/kg single i.p. injection of Cis on the seventh day, and third, fourth, and fifth groups were treated orally PD at 25, 50, and 100 mg/kg/day, respectively for 10 days starting seven days before Cis injection and 7 mg/kg single i.p. Cis was injected on the seventh day. Cis resulted in significant increase malondialdehyde levels and decreased glutathione levels. In addition, Cis treatment decreased superoxide dismutase and catalase activities in erythrocyte and tissues. Also, Cis treatment caused to increase DNA damage and affected serum biochemic
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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