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Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088886" target="_blank" >RIV/00216224:14110/16:00088886 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1186/s12935-016-0289-2" target="_blank" >http://dx.doi.org/10.1186/s12935-016-0289-2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s12935-016-0289-2" target="_blank" >10.1186/s12935-016-0289-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

  • Original language description

    Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible for its primary antineoplastic action. However, other non-DHFR-mediated effects of methotrexate have been recently discovered, which might be very useful in the development of new strategies for the treatment of pediatric malignancies. The principal goal of this study was to analyze the possible impact of clinically achievable methotrexate levels on cell proliferation, mechanisms of epigenetic regulation (DNA methylation and histone acetylation), induced differentiation and the expression of differentiation-related genes in six osteosarcoma cell lines. Methotrexate significantly decreased the proliferation of Saos-2 cells exclusively, suggesting that this reference cell line was sensitive to the DHFR-mediated effects of methotrexate.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FG - Paediatrics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT14327" target="_blank" >NT14327: DHFR- and non-DHFR-mediated effects of methotrexate on cellular level: a study on cell lines derived from pediatric solid tumors</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer Cell International

  • ISSN

    1475-2867

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    14

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    "nestránkováno"

  • UT code for WoS article

    000371005700001

  • EID of the result in the Scopus database