Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088907" target="_blank" >RIV/00216224:14110/16:00088907 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/mp.2016.89" target="_blank" >http://dx.doi.org/10.1038/mp.2016.89</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/mp.2016.89" target="_blank" >10.1038/mp.2016.89</a>

Result language

angličtina

Original language name

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Original language description

Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NV15-31063A" target="_blank" >NV15-31063A: Cellular-signature profiling: leading to tailored treatment for Schizophrenic patients</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Psychiatry

ISSN

1359-4184

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

1167-1179

UT code for WoS article

000382328900003

EID of the result in the Scopus database

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