Pluripotent stem cells and gene therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F13%3A00068030" target="_blank" >RIV/00216224:14330/13:00068030 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060657
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/23353080" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23353080</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trsl.2013.01.001" target="_blank" >10.1016/j.trsl.2013.01.001</a>
Alternative languages
Result language
angličtina
Original language name
Pluripotent stem cells and gene therapy
Original language description
Human pluripotent stem cells represent an accessible cell source for novel cell-based clinical research and therapies. With the realization of induced pluripotent stem cells (iPSCs), it is possible to produce almost any desired cell type from any patient's cells. Current developments in gene modification methods have opened the possibility for creating genetically corrected human iPSCs for certain genetic diseases that could be used later in autologous transplantation. Promising preclinical studies havedemonstrated correction of disease-causing mutations in a number of hematological, neuronal, and muscular disorders. This review aims to summarize these recent advances with a focus on iPSC generation techniques, as well as gene modification methods. Wewill then further discuss some of the main obstacles remaining to be overcome before successful application of human pluripotent stem cell-based therapy arrives in the clinic and what the future of stem cell research may look like.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Translational Research
ISSN
1931-5244
e-ISSN
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Volume of the periodical
161
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
284-292
UT code for WoS article
000316837400008
EID of the result in the Scopus database
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