Electrochemical and spectral behaviour of miR-34a-5p

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00089932" target="_blank" >RIV/00216224:14110/16:00089932 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00706-015-1600-y" target="_blank" >http://dx.doi.org/10.1007/s00706-015-1600-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-015-1600-y" target="_blank" >10.1007/s00706-015-1600-y</a>

Result language
angličtina
Original language name
Electrochemical and spectral behaviour of miR-34a-5p
Original language description
MicroRNAs are a family of small noncoding RNAs, regulating gene expression at the post-transcriptional level and playing a crucial role as potential biomarkers and targets for many types of cancer. Our attention was given to electrochemical and spectral studies of miR-34a-5p, related to head and neck and also prostate cancer. Voltammetric experiments on a hanging mercury drop electrode and circular dichroic spectroscopic experiments in buffer solutions were performed in the range of pH from 3 to 6 and from 3 to 8, respectively. The miRNA and its DNA sequential analogues (miDNA) provided interesting and significantly different results. A comparison of miRNA and both miDNA (U) and (T) showed the effect of substitution of ribose to deoxyribose, and structural diversity of nucleic acids was confirmed by both electrochemical and spectral methods.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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