Chromatic pupillography in hemianopia patients with homonymous visual field defects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098414" target="_blank" >RIV/00216224:14110/17:00098414 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00417-017-3721-y" target="_blank" >http://dx.doi.org/10.1007/s00417-017-3721-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00417-017-3721-y" target="_blank" >10.1007/s00417-017-3721-y</a>

Result language

angličtina

Original language name

Chromatic pupillography in hemianopia patients with homonymous visual field defects

Original language description

The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways. 12 patients (59.1 +/- 18.8 years) with homonymous hemianopia due to post-geniculate lesions of the visual pathway and 20 normal controls (58.6 +/- 12.9 years) were examined using chromatic pupillography: stimulus intensity was 28 lx corneal illumination, stimulus duration was 4.0 s, and the stimulus wavelengths were 420 +/- 20 nm (blue) and 605 +/- 20 nm (red), respectively. The examined parameters were baseline pupil diameter, latency, and relative amplitudes (absolute amplitudes compared to baseline), measured at maximal constriction, at 3 s after stimulus onset, at stimulus offset, and at 3 s and 7 s after stimulus offset. The relative amplitudes for the red stimulus were significantly smaller for hemianopia patients compared to the normal controls [maximal constriction: 35.6 +/- 5.9% (hemianopia) to 42.3 +/- 5.7% (normal); p = 0.004; 3 s after stimulus onset: p = 0.004; stimulus offset: p = 0.001]. No significant differences in any parameter were found between the two groups using the blue stimulus. The results support the hypothesis that the ipRGC pathway is mainly subcortical, whereas a second, non-ipRGC pathway via the occipital cortex exists.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30207 - Ophthalmology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Graefes Archive for Clinical and Experimental Ophthalmology

ISSN

0721-832X

e-ISSN

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Volume of the periodical

255

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1837-1842

UT code for WoS article

000407587600020

EID of the result in the Scopus database

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