The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098656" target="_blank" >RIV/00216224:14110/17:00098656 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.burnso.2017.05.007" target="_blank" >http://dx.doi.org/10.1016/j.burnso.2017.05.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.burnso.2017.05.007" target="_blank" >10.1016/j.burnso.2017.05.007</a>

Result language
angličtina
Original language name
The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report
Original language description
Toxic epidermal necrolysis (TEN) represents the most serious affection within the SCARs group (Severe Cutaneous Adverse Reactions). It is an autoimmune disease manifested by extensive epidermal and mucosal exfoliation. The basic approach in the therapy of patients suffering from toxic epidermal necrolysis is the administration of immunosuppressive medications. Comet assay is a fast, sensitive and relatively easy method used to detect DNA damage levels. We present a case report of a woman with toxic epidermal necrolysis treated with cyclosporine A. During the therapy, comet assay was used to detect the level of DNA damage of circulating lymphocytes and it helped us to reveal qualitative abnormalities in these cells.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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