Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00117881" target="_blank" >RIV/00216224:14110/20:00117881 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/21/20/7688" target="_blank" >https://www.mdpi.com/1422-0067/21/20/7688</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21207688" target="_blank" >10.3390/ijms21207688</a>
Alternative languages
Result language
angličtina
Original language name
Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer
Original language description
Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
1422-0067
Volume of the periodical
21
Issue of the periodical within the volume
20
Country of publishing house
CH - SWITZERLAND
Number of pages
27
Pages from-to
1-27
UT code for WoS article
000585581600001
EID of the result in the Scopus database
2-s2.0-85092652348