Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F20%3A00073979" target="_blank" >RIV/65269705:_____/20:00073979 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1422-0067/21/20/7688" target="_blank" >https://www.mdpi.com/1422-0067/21/20/7688</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms21207688" target="_blank" >10.3390/ijms21207688</a>

Result language

angličtina

Original language name

Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer

Original language description

Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

20

Country of publishing house

CH - SWITZERLAND

Number of pages

27

Pages from-to

7688

UT code for WoS article

000585581600001

EID of the result in the Scopus database

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