Derivation and characterization of clinical-grade human embryonic stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120147" target="_blank" >RIV/00216224:14110/21:00120147 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Derivation and characterization of clinical-grade human embryonic stem cells
Original language description
Human embryonic stem cells (hESCs) represent an unlimited source of cells for the differentiation into the derivates that are suitable for a variety of biomedical applications. Cell therapies, disease modeling, and drug testing, which are examples of application, demand robust and replicable protocols for the derivation and differentiation of hESCs. Nevertheless, allogeneic background and undefined culture conditions are limitations of current protocols. Therefore, here we present the generation of the two sex-discordant sibling hESC lines, MUNIe008-A and MUNIe009-A, using the mechanical biopsy of vitrified-thawed embryos (excess for fertility treatment) under xeno- and feeder-free conditions. The presented approach is applicable for deriving high-quality clinicalgrade hESC lines for a variety of clinical applications.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/NV18-08-00412" target="_blank" >NV18-08-00412: Clinical grade human embryonic stem cells: derivation and characterization</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů