Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120218" target="_blank" >RIV/00216224:14110/21:00120218 - isvavai.cz</a>
Result on the web
<a href="https://ieeexplore.ieee.org/document/9629577" target="_blank" >https://ieeexplore.ieee.org/document/9629577</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/EMBC46164.2021.9629577" target="_blank" >10.1109/EMBC46164.2021.9629577</a>

Result language
angličtina
Original language name
Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
Original language description
Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
Czech name
—
Czech description
—

Project
<a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ISBN
—
ISSN
2375-7477
e-ISSN
2694-0604
Number of pages
4
Pages from-to
5816-5819
Publisher name
IEEE
Place of publication
Neuveden
Event location
Virtual
Event date
Jan 1, 2021
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000760910505098

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