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Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00551391" target="_blank" >RIV/68081731:_____/21:00551391 - isvavai.cz</a>

  • Result on the web

    <a href="https://ieeexplore.ieee.org/document/9629577" target="_blank" >https://ieeexplore.ieee.org/document/9629577</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1109/EMBC46164.2021.9629577" target="_blank" >10.1109/EMBC46164.2021.9629577</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

  • Original language description

    Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures - mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay. Clinical Relevance: Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

    <a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

  • ISBN

    978-1-7281-1179-7

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    5816-5819

  • Publisher name

    IEEE

  • Place of publication

    New York

  • Event location

    online

  • Event date

    Nov 1, 2021

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000760910505098