Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128412" target="_blank" >RIV/00216224:14110/22:00128412 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/22:43880393 RIV/62157124:16270/22:43880393
Result on the web
<a href="http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php" target="_blank" >http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.17221/56/2022-VETMED" target="_blank" >10.17221/56/2022-VETMED</a>

Result language
angličtina
Original language name
Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs
Original language description
The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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